TABLE 1.
MICs of β-lactams for strains tested
| β-Lactam(s) | MIC (μg/ml)a |
|||||
|---|---|---|---|---|---|---|
| A. baumannii 25 | A. baumannii(pOXA-253) | A. baumannii CIP7010 | E. coli TOP10(pTOPO-OXA-253) | E. coli TOP10(pTOPO-OXA-143) | E. coli TOP10 | |
| Amoxicillin | >256 | >256 | 32 | >256 | >256 | 4 |
| Amoxicillin + CLAb | >256 | >256 | 32 | 128 | 64 | 4 |
| Ticarcillin | >256 | >256 | 8 | >256 | 128 | 4 |
| Ticarcillin + CLA | >256 | >256 | 8 | 128 | 64 | 4 |
| Piperacillin | >256 | >256 | 16 | 8 | 4 | 1 |
| Ceftazidime | >256 | 4 | 4 | 0.38 | 0.38 | 0.06 |
| Cefotaxime | >256 | 12 | 2 | 0.12 | 0.12 | 0.12 |
| Cefepime | 4 | 3 | 2 | 0.12 | 0.12 | 0.12 |
| Aztreonam | >256 | 24 | 8 | 0.06 | 0.09 | 0.06 |
| Imipenem | >32 | 32 | 0.25 | 1 | 0.38 | 0.06 |
| Ertapenem | NDc | ND | ND | 1 | 0.75 | 0.06 |
| Meropenem | >32 | >32 | 0.25 | 0.5 | 0.19 | 0.01 |
a
The MICs were determined by Etest.
b
CLA, clavulanic acid at a fixed concentration of 4 μg/ml.
c
ND, not determinable due to the natural resistance of these Gram-negative rods to ertapenem.