TABLE 4.
Linezolid pharmacokinetic parameters for the population in the basic and final model estimates and relative standard errors (RSEs)
| Parameter | Basic model |
Final model |
||
|---|---|---|---|---|
| Estimate | RSE (%) | Estimate | RSE (%) | |
| ka (h−1) | 2.7 | 2.7 | ||
| V (liters) | 47.5 | 8 | 47.1 | 8 |
| CL (liters/h) | 4.37 | 12 | 4.31 | 9 |
| βCL_weight | 1.33 | 31 | ||
| βCL_age | −0.81 | 33 | ||
| ωka | 1.92 | 28 | 2.67 | 22 |
| ωV | 0.242 | 39 | 0.243 | 40 |
| ωCL | 0.611 | 14 | 0.445 | 14 |
| a (μg/ml) | 1.16 | 26 | 1.15 | 26 |
| b | 0.07 | 37 | 0.07 | 37 |
ka, absorption rate constant; CL, clearance; V, volume of distribution; βCL_weight, weight effect on CL centered to the mean; βCL_age, age effect on CL centered to the mean; ωka, ωV, and ωCL, standard deviation for interpatient variability; a and b, parameters of error model.