FIG 3.

In vivo evaluation of parasite burden after combined therapy with tamoxifen and amphotericin B. Treatment was initiated 5 weeks postinfection. Images were collected after the end of treatment at 9 weeks postinfection. Images are of representative animals treated with tamoxifen and amphotericin B (alone or in association). The bar on the right shows a pseudo-color scale representing light intensities. NT, untreated; Tam6.5, Tam26, treated with 6.5 or 26 mg/kg/day tamoxifen alone; AmB1.2, AmB4, treated with 1.2 or 4 mg/kg/day amphotericin B alone; Tam+AmB, treated with combinations of the two drugs in the doses indicated.