FIG 4.
Combined therapy with tamoxifen and amphotericin B. Evaluation of lesion size (A) and parasite burden (B) in mice (n = 6) treated with tamoxifen (6.5 or 26 mg/kg/day) and/or amphotericin B (1.2 or 4 mg/kg/day) at the end of treatment. NT, untreated; Tam6.5, Tam26, treated with 6.5 or 26 mg/kg/day tamoxifen alone; AmB1.2, AmB4, treated with 1.2 or 4 mg/kg/day amphotericin B alone; Tam+AmB, treated with combinations of the two drugs in the doses indicated; Ph/sec/cm2, photons per second per square centimeter. *, P < 0.05 versus the untreated group and versus amphotericin B 1.2 mg/kg/day; •, P < 0.05 versus tamoxifen 6.5 mg/kg/day.