TABLE 1.
SNPs identified in ntrTv genes
| Gene | SNP | Amino acid change | No. (%) of resistant isolates with: |
No. (%) of sensitive isolates with: |
Pa | ||
|---|---|---|---|---|---|---|---|
| SNP present | SNP absent | SNP present | SNP absent | ||||
| ntr3Tv | A176T | Q59L | 1 (3.1) | 31 (97) | 0 (0.0) | 33 (100) | |
| G199A | G67R | 21 (66) | 11 (34) | 22 (69) | 10 (31) | ||
| G214A | G72R | 0 (0.0) | 32 (100) | 2 (6.1) | 31 (94) | ||
| G274A | D92N | 9 (28) | 23 (72) | 4 (12) | 30 (88) | ||
| A385G | S129G | 31 (97) | 1 (3.1) | 33 (97) | 1 (2.9) | ||
| T506C | L169P | 0 (0.0) | 32 (100) | 2 (5.9) | 32 (94) | ||
| A515C | E171A | 0 (0.0) | 32 (100) | 1 (2.9) | 33 (97) | ||
| ntr4Tv | T152A | V51D | 3 (6.0) | 47 (94) | 5 (10) | 45 (90) | |
| G208C | E70Q | 3 (6.0) | 47 (94) | 5 (10) | 45 (90) | ||
| G76C | D26H | 30 (60) | 20 (40) | 16 (32) | 34 (68) | 0.0056 | |
| C213G | Y71STOP | 33 (66) | 17 (34) | 17 (34) | 33 (66) | 0.0016 | |
| C318A | H106Q | 24 (48) | 26 (52) | 12 (24) | 38 (76) | 0.014 | |
| ntr6Tv | G259A | E87K | 6 (12) | 44 (88) | 1 (2.0) | 49 (98) | |
| T458C | V153A | 1 (2.0) | 49 (98) | 1 (2.0) | 49 (98) | ||
| A238T | K80STOP | 20 (40) | 30 (60) | 2 (4.0) | 48 (96) | <0.0001 | |
| G427C | E143Q | 38 (76) | 12 (24) | 18 (36) | 32 (64) | 0.0001 | |
| T476C | V159A | 20 (40) | 30 (60) | 2 (4.0) | 48 (96) | <0.0001 | |
| ntr9Tv | C288A | F96L | 1 (3.7) | 26 (96) | 0 (0.0) | 28 (100) | |
| T350C | V117A | 4 (15) | 23 (85) | 0 (0.0) | 27 (100) | ||
| ntr10Tv | T395C | V132A | 0 (0.0) | 17 (100) | 1 (14) | 6 (86) | |
a
P values determined by two-tailed Fisher's exact test.