TABLE 3.
Association of ntr4Tv C213G (Y71STOP) and ntr6Tv A238T (K80STOP) SNPs with metronidazole resistance
| Phenotype | No. (%) of isolates with indicated genotype |
|||
|---|---|---|---|---|
| ntr4Tv reference and ntr6Tv referencea | ntr4Tv C213G (Y71STOP) SNP and ntr6Tv reference | ntr4Tv reference and ntr6Tv A238T (K80STOP) SNP | ntr4Tv C213G (Y71STOP) SNP and ntr6Tv A238T (K80STOP) SNP | |
| Total | 85 (43) | 76 (39) | 2 (1.0) | 34 (17) |
| Susceptible | 56 (57) | 38 (39) | 0 (0) | 4 (4.1) |
| Resistantb | 29 (29) | 38 (38) | 2 (2.0) | 30 (30) |
| Low | 4 (18) | 13 (59) | 0 (0) | 5 (23) |
| Moderate | 10 (33) | 10 (33) | 0 (0) | 10 (33) |
| High | 15 (32) | 15 (32) | 2 (4.3) | 15 (32) |
a
Reference sequence refers to that found in the sequenced G3 isolate.
b
Resistance is defined as low (MLC, ≤100 μg/ml), moderate (MLC, 200 μg/ml), or high (MLC ≥400 μg/ml); isolates with MLC values between 100 and 400 μg/ml were categorized as moderate.