TABLE 4.

Results of CART analysis for microbiological eradication (outcome) at EOT for a BL and BL/EOT microorganism

Outcome and predictor	Split value	Successa in group with value more than the split value (no.)	Failureb in group with value more than the split value (no.)	Successa in group with value less than or equal to the split value (no.)	Failureb in group with value less than or equal to the split value (no.)	Pc
Microbiological eradication at EOT of BL microorganismd (243 patients)
MICe	2	69	27	136	11	<0.0001
%fT>MIC	100	157	14	48	24	<0.0001
%fT>MICf	51.2	168	37	19	19	<0.0001
fAUC/MIC	197.8	103	4	102	34	<0.0001
fCmax/MIC	9.31	150	12	55	26	<0.0001
Microbiological eradication at EOTg (251 patients)
MICe	8	47	46	143	15	<0.0001
%fT>MIC	62.2	154	16	36	45	<0.0001
fAUC/MIC	12.1	154	16	36	45	<0.0001
fCmax/MIC	2.22	155	16	35	45	<0.0001

^aFailure instead of success for MIC.

^bSuccess instead of failure for MIC.

^cThe P value refers to the significance of the split value.

^dOutcome: eradication at end of treatment of the microorganisms cultured at baseline.

^eIn 2-fold dilution series.

^fAlternative split.

^gOutcome: positive or negative culture at end of treatment.