TABLE 2.
Pharmacokinetic parameters of CMS and formed colistin in plasma following a single i.v. infusion of CMS (150 mg of CBA)
| Subject | Colistin methanesulfonate |
Colistin |
||||||
|---|---|---|---|---|---|---|---|---|
| AUC0-∞ (mg · h/liter) | CL (liters/h)a | Vss (liters)b | t1/2 (h)c | AUC0-∞ (mg · h/liter) | t1/2 (h)d | Cmax (mg/liter) | fTmax (h) | |
| 1 | 46.9 | 8.00 | 23.5 | 3.17 | 4.91 | 6.04 | 0.40 | 4.9 |
| 2 | 71.7 | 5.23 | 12.2 | 1.99 | NCe | NC | 0.77 | 4.8 |
| 3 | 62.3 | 6.02 | 21.4 | 3.12 | 8.14 | 8.42 | 0.53 | 5.1 |
| 4 | 75.1 | 4.99 | 16.1 | 3.23 | 7.28 | 7.38 | 0.52 | 5.1 |
| 5 | 65.2 | 5.75 | 16.6 | 2.55 | 10.2 | 9.03 | 0.62 | 4.8 |
| 6 | 65.1 | 5.76 | 12.0 | 1.92 | 5.87 | 5.84 | 0.51 | 4.7 |
a
The mean (SD) of the CL for all 6 subjects was 5.96 liters/h (1.07 liters/h).
b
The mean (SD) of the Vss for all 6 subjects was 16.9 liters (4.68 liters).
c
The mean (SD) of the t1/2 for colistin methanesulfonate for all 6 subjects was 2.66 h (0.60 h).
d
The mean (SD) of the t1/2 for colistin for all 6 subjects was 7.34 h (1.41 h).
e
NC, not calculated, the tlast for subject 2 was 8.71 h, as the 12-h sample could not be collected; thus, we were not able to estimate the t½ or AUC0-∞.