TABLE 4.
Pharmacokinetic parameters of formed colistin in sputum following nebulization of CMS
| Subject | Parameters with nebulized administration of CMS at a dose of: |
|||||
|---|---|---|---|---|---|---|
| 2 million IUa,b |
4 million IU |
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| AUC0-tlast (mg · h/liter) | Cmax (mg/liter)c | Tmax (h) | AUC0-tlast (mg · h/liter)d | Cmax (mg/liter)e | Tmax (h) | |
| 1 | 30.3 | 3.63 | 1.3 | 61.5 | 7.63 | 1.5 |
| 2 | 24.3 | 3.72 | 4.3 | 88.9 | 15.2 | 12 |
| 3 | 73.1 | 11.3 | 4.3 | 104 | 16.4 | 1.3 |
| 4 | 18.9 | 2.09 | 1.4 | 37.0 | 4.10 | 4.4 |
| 5 | 37.5f | 7.18 | 4.5 | 129f | 21.2 | 2.9 |
| 6 | 62.2 | 8.15 | 2.4 | 122 | 12.1 | 5.2 |
a
No statistically significant difference for dose-normalized AUC0-tlast and dose-normalized Cmax and Tmax between the two nebulized CMS doses.
b
The mean (SD) of the AUC0-tlast for all 6 subjects was 41.8 mg · h/liter (24.3 mg · h/liter).
c
The mean (SD) of the Cmax for all 6 subjects was 6.00 mg/liter (3.45 mg/liter).
d
The mean (SD) of the AUC0-tlast for all 6 subjects was 82.6 mg · h/liter (33.7 mg · h/liter).
e
The mean (SD) of the Cmax for all 6 subjects was 12.8 mg/liter (6.19 mg/liter).
f
Subject 5 tlast following nebulized CMS doses was 8.3 h.