TABLE 5.

Pharmacokinetic parameters of CMS in plasma following nebulization of 2 and 4 million IU of CMS

Subject	Parameters with nebulized administration of CMS at dose of:
	2 million IU			4 million IU
	AUC0-∞ (mg · h/liter)a	Cmax (mg/liter)b	Tmax (h)a	AUC0-∞ (mg · h/liter)c	Cmax (mg/liter)d	Tmax (h)
1	1.39	0.20	1.3	1.67	0.21	2.6
2	1.16	0.22	0.74	2.41	0.32	2.3
3	1.27	0.22	1.3	2.53	0.31	1.3
4	3.53	0.30	1.4	3.53	0.48	1.3
5	3.77	0.13	2.3	4.10	0.27	2.9
6	1.26	0.24	0.82	2.46	0.37	0.8

^aNo statistically significant difference for dose-normalized AUC_o-∞ and T_max between the two nebulized CMS doses. The mean (SD) of the AUC_o-∞ for the 2 million IU dose for all 6 subjects was 2.06 mg · h/liter (1.24 mg · h/liter).

^bStatistically significant difference for dose-normalized C_max between the two nebulized CMS doses (P < 0.05). The mean (SD) of the C_max for the 2 million IU dose for all 6 subjects was 0.22 mg/liter (0.055 mg/liter).

^cThe mean (SD) of the AUC_o-∞ for the 4 million IU dose for all 6 subjects was 2.78 mg · h/liter (0.88 mg · h/liter).

^dThe mean (SD) of the C_max for the 4 million IU dose for all 6 subjects was 0.33 mg/liter (0.092 mg/liter).