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Toxic MPs activate the S. aureus heme detoxification machinery. Activation of the HssRS/HrtAB system was monitored using a xylE reporter gene under the control of the hrtAB promoter as previously described (13). Growth curve analyses were performed in triplicate. Error bars correspond to 1 standard deviation of the mean. The asterisks (*) highlight compounds that were found to be toxic to S. aureus by growth curve analysis.
