TABLE 2.
Murine virulence studies of F. tularensis Schu S4, F. tularensis waaB::TrgTn, and F. tularensis waaL::TrgTn strains
| Strain and infection route | Infection dose (CFU) | Survival ratio (no. of survivors/no. of mice in group) | Mean time to death (days) |
|---|---|---|---|
| i.p. infection | |||
| Schu S4 | 12 | 0/5 | 5 |
| waaY::TrgTn | 1.8 × 104 | 5/5 | >14 |
| 1.8 × 105 | 5/5 | >14 | |
| 1.8 × 106 | 5/5 | >14 | |
| 2.2 × 107 | 1/5 | 3.75, >14 | |
| 2.2 × 108 | 0/5 | 3.2 | |
| waaL::TrgTn | 1.2 × 104 | 5/5 | >14 |
| 1.2 × 105 | 5/5 | >14 | |
| 1.2 × 106 | 0/5 | 5 | |
| 2.4 × 107 | 1/5 | 3.75, >14 | |
| 2.4 × 108 | 0/5 | 2.8 | |
| i.n. infection | |||
| Schu S4 | 16 | 0/5 | 6 |
| waaY::TrgTn | 1.3 × 103 | 5/5 | >26 |
| 1.3 × 104 | 2/5 | 19.3, >26 | |
| 1.3 × 105 | 1/4 | 16.6, >26 | |
| 1.3 × 106 | 0/5 | 18 | |
| 1.3 × 107 | 0/5 | 19.8 | |
| 1.3 × 108 | 0/5 | 15.8 | |
| waaL::TrgTn | 7 × 102 | 5/5 | >26 |
| 2.4 × 104 | 0/5 | 16.2 | |
| 7 × 104 | 1/5 | 19, >26 | |
| 7 × 105 | 0/5 | 12 | |
| 7 × 106 | 1/5 | 15, >26 | |
| 7 × 107 | 0/5 | 11.6 |