FIG 1.

(A) Kaplan-Meier curves showing the survival proportions of animals with PM treated with antibiotics and MMP and/or TACE inhibitors or the vehicle (succinylated gelatin). Results represent spontaneous deaths and killing for ethical reasons (severe disease with a clinical score of <2). Ro 32-3555 reduced the mortality rate significantly (**, P < 0.005) to 14.5% compared to that of control littermates (37.1%), while Ro 32-7315 did not alter the mortality rate significantly (56.3%, P < 0.05). (B) Ro 32-3555 reduced the concentrations of TNF in CSF significantly at 18 hpi, while Ro 32-7315 reduced TNF levels at 18 and 27 hpi compared to those of littermates treated with the vehicle. At 42 hpi TNF values were close to the limit of detection (*, P < 0.05).