FIG 7.

IFN-γ and pathogen-specific IgM are not essential for host defense against IOE infection in the absence of IFN-αR signaling. Ifnar^−/− mice were treated with anti-IFN-γ or PBS every other day, beginning on day 2 post-IOE infection. (A) Bacterial burden in the spleens and lungs was measured in Ifnar^−/− mice treated with or without anti-IFN-γ antibodies (day 8 postinfection). (B) Survival curves of WT mice treated with PBS and Ifnar^−/− mice that received anti-IFN-γ are shown. (C) Serum IFN-γ concentrations in Ifnar^−/− mice that received anti-IFN-γ treatment are shown. Number symbols (#) indicate a significant difference between the groups as indicated (P < 0.05). “n.s.” indicates no significant difference (P > 0.05). “n.d.” indicates not detectable. For data shown in panels A and C, at least five animals for each group were used. For panel B, at least nine animals for each group were used.