FIG 8.

IFN-αR signaling in the nonhematopoietic system contributes significantly to host death during IOE infection. Reverse chimeric mice (WT BM to Ifnar^−/− recipients and Ifnar^−/− BM to WT recipients, respectively) were generated and subsequently infected with IOE. (A) Survival curves for reverse chimeric mice during IOE infection are shown. P value shown (log-rank [Mantel-Cox] test) indicates the comparison of survival curves between the two reverse chimeric mice. (B) Serum IFN-γ concentrations in reverse chimeric mice at day 8 postinfection are shown. (C) Serum IFN-α and IFN-β in reverse chimeric mice at day 8 postinfection are shown. (D) IOE burden in the spleens and livers of reverse chimeric mice at day 8 postinfection is shown. Number symbols (#) indicate a significant difference between the groups as indicated (P < 0.05). “n.s.” indicates no significant difference (P > 0.05). For data shown in panel A, at least eight animals for each group were used. For panels B and C, three animals for each group were used.