FIG 3.

Neutrophils select SpeB^A− variants. (A and B) SpeB^A−% of GAS isolates recovered from the skin infection site of MGAS2221 in C57BL/6 mice with intraperitoneal treatment with DPBS or RB6-8C5 (A) and 2A3 (subtype MAb control) or 1A8 (B) at day 4 post-subcutaneous infection with 5 × 10⁷ CFU of MGAS2221. (C) Levels of neutrophil infiltration at the skin infection site of MGAS2221 in BALB/c and CXCR2^−/− mice at 24 h postinoculation. (D) SpeB^A−% of GAS isolates recovered from the skin infection site in BALB/c and CXCR2^−/− mice at day 4 post-subcutaneous infection with MGAS2221.