FIG 2.

Effect of CARD9 deficiency on the histological changes after infection with C. neoformans. WT and CARD9 KO mice were infected intratracheally with C. neoformans. Sections of lungs on day 14 postinfection were stained with H-E or PAS and observed under a light microscope at magnifications of ×200 (A) and ×1,000 (B). Representative pictures from three mice are shown. (C) The lung leukocytes prepared on day 14 postinfection were stained with Diff-Quick and observed under a light microscope. Representative pictures from three mice are shown. Magnification, ×200. The number of cells in each leukocyte fraction was counted. Each column represents the mean and SD for three mice. NS, not significant; *, P < 0.05.