FIG 4.

Role of early produced IFN-γ on the host defense against cryptococcal infection. (A) WT and CARD9 KO mice were infected intratracheally with C. neoformans, and the number of live colonies in lungs was counted on day 5 after infection. Data are means and SD for five mice. Experiments were repeated twice with similar results. *, P < 0.05. (B) WT mice were infected intratracheally with C. neoformans and injected intraperitoneally with anti-IFN-γ MAb or control rat IgG at 200 μg/mouse 2 h before infection and intratracheally with the same Ab at 25 μg/mouse when they were infected. The number of live colonies in lungs was counted on day 14 after infection. Data are means and SD for five mice. Experiments were repeated twice with similar results. *, P < 0.05; NS, not significant.