FIG 7.

Effect of CARD9 deficiency on the chemokine production. (A) WT and CARD9 KO mice were infected intratracheally with C. neoformans. Expression of CCL3, CCL4, CCL5, CXCL9, and CXCL10 in lungs was measured on day 3. Each column represents the mean ± SD of five mice. (B) BM-DCs were cultured with C. neoformans (MOI, 1) or LPS (1 μg/ml) for 24 h, and expression of CCL3, CCL4, and CCL5 was measured. Data are means and SD from triplicate cultures. Experiments were repeated twice with similar results. NS, not significant; *, P < 0.05.