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. 2014 May;82(5):2125–2134. doi: 10.1128/IAI.01491-14

FIG 6.

FIG 6

Protective immunity in BALB/c mice was associated with a Th17/IL-17A-polarized response, compared with a Th1/IFN-γ-polarized response in C57BL/6 mice. S. aureus-specific T cell responses were assessed 8 weeks after primary infection with S. aureus by ELISpot (n = 3 to 5 mice/group). IFN-γ (A) or IL-17A (B) produced by S. aureus-stimulated splenocytes was increased in C57BL/6 and BALB/c mice after primary infection compared with results for naive controls. (A) IFN-γ responses were higher for C57BL/6 mice than for BALB/c mice. (B) In contrast, IL-17A responses were higher for BALB/c mice than for C57BL/6 mice. (C) IFN-γ/IL-17A ratios were higher for C57BL/6 mice than for BALB/c mice. Data are presented as means ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; by one-way ANOVA with Tukey's posttest. The results of one representative experiment are presented; each was repeated at least once.