FIG 5.

Innate immune response to sequential HJ3-5 and H77S.2 infections in chimpanzee 4x0193. (A) Serum cytokine levels measured by Luminex assay during the period of HJ3-5 infection and the first 26 weeks of persistent H77S.2 infection: (top) IL-12, IP-10, and MIP-1β serum levels; (bottom) inflammasome-related serum cytokine levels of IL-1β and IL-18. (B) Intrahepatic ISG mRNA transcript levels measured by real-time qRT-PCR 2, 26, 79, and 194 weeks after intravenous inoculation of cell culture-derived H77S.2 virus. (C) Intrahepatic IFN transcripts 2 and 194 weeks after infection with H77S.2 virus: IFN-β, IL-28 (IFN-λ2 and -λ3), IL-29 (IFN-λ1), and IFN-γ.