TABLE 1.
Chimpanzee infections with JFH1 replicase-containing HCV produced in cell culture
| Animal | Virus | Inoculum titer | Viremia time frame (wk) | Time of maximum viremia (wk) | Maximum viremia (GE/ml) | ALT elevation | Time of anti-HCV ELISA (wk) | Reference |
|---|---|---|---|---|---|---|---|---|
| x0483 | FL-J6/JFH1 | 106 TCID50 | 1–15 | 2 | ∼2 × 104 | No | 10 | 50 |
| x0495 | FL-J6/JFH1 | 106 TCID50 | 1–6, 15 | 2 | ∼7 × 104 | No | 13 | 50 |
| x0215 | JFH1 | 8.0 × 106 GE | 2–5 | 4 | 2 ×103 | No | No | 12 |
| 10274 | JFH1 | 9.6 × 106 GE | 2–8 | 4 | ∼1 ×103 | No | No | 16 |
| 4x0193 | HJ3-5 | 106 FFU | 1–3 | 1 | 1 ×104 | No | Noa | This report |
a
The increase in OD did not reach the threshold for a positive result.