TABLE 3.

Changes in H77S.2 virus sequence during persistent infection in chimpanzee 4x0193^h

^aNS3p, protease domain; NS3h, helicase domain; NS5a domains (d1, d2, and d3) are according to Tellinghuisen et al. (68).

^bIdentical substitution at this position in chimpanzee 1530 (39).

^cIdentical substitution at this position in chimpanzee 1564 (39).

^dAlternative amino acid substitutions (A2412D, D2486E) are at this position in chimpanzee 1564 (39).

^eIdentical substitution at this position in chimpanzee 1535 (59).

^fIdentical substitution at this position in chimpanzee 1536 (59).

^gAlternative amino acid substitution (V1745A, D2486E) at this position in chimpanzee 1535 (59).

^hCell culture-adaptive mutations and reversions are shown in boldface; synonymous nucleotide substitutions are shaded.