TABLE 4.
Nonsynonymous substitutions occurring within potential class 1 epitopes in H77S.2 virus during persistent infection in chimpanzee 4x0193
| Protein | Amino acid substitution(s) | Chimpanzee class I | Chimpanzee epitope sequence | Mutation direction |
|---|---|---|---|---|
| E2 | L546M | B1301 | TRPPLGNWFb | Away |
| E2 | M608L | Not mappeda | ITPRCMVDYPYRLWHYPC | Toward |
| NS3h | S1358P | B1301 | VPHPNIEEV | Toward |
| NS3h | I1568M | Not mappeda | FTGLTHIDAHFLSQTKQS | Away |
| NS3h | I1641V, I1655V | Not mappeda | ITKYIMTCMSADLEIV | Away |
| NS5A d1 | A1997T | B0101 | KTWLKAKLM | Away |
| NS5B | K2518R | A0301 | CSLTPPHSAK | Away |
a
Epitopes were identified using CD8+ T cell lines, but class I molecules responsible for presentation were not mapped.
b
Residue undergoing substitution is underlined.