FIG 1.

Foreskin is enriched with memory CD4⁺ and CD8⁺ T cells. CD4⁺ and CD8⁺ T cells were assessed for CD28 and CD95 expression to identify naive (CD28⁺ CD95⁻), central/transitional memory (CM/TM; CD28⁺ CD95⁺), and effector memory (EM; CD28⁻ CD95⁺) T cells in paired PBMC and foreskin specimens. The proportions of naive, CM/TM, and EM CD4⁺ and CD8⁺ T cells in PBMC and foreskin are presented for infected animals (A), vaccinated animals (B), and sham-vaccinated animals (C). *, P < 0.05; **, P < 0.01; ***, P < 0.001 (two-tailed Student t test) for comparison of the proportion of CM/TM CD4⁺ or CD8⁺ T cells between PBMC and foreskin. Error bars represent the standard errors of the mean (SEM).