FIG 2.

The proportion of transitional memory T cells is higher in foreskin than peripheral blood. Memory (CD95⁺) T cells were assessed for CCR7 and CD28 expression in a subset of animals to identify effector memory cells (EM; CD28⁻ CD95⁺ CCR7⁻) and differentiate transitional memory cells (TM; CD28⁺ CD95⁺ CCR7⁻) from fully differentiated central memory cells (CM; CD28⁺ CD95⁺ CCR7⁺) as previously described (18). The proportions of EM, TM, and CM CD4⁺ and CD8⁺ T cells in matched PBMC and foreskin specimens are presented for infected animals (A) and vaccinated animals (B). **, P < 0.01 (two-tailed Student t test) for comparison of the proportion of TM CD4⁺ or CD8⁺ T cells between PBMC and foreskin. Error bars represent the SEM.