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. 2014 Apr;88(7):3623–3635. doi: 10.1128/JVI.03663-13

FIG 2.

FIG 2

Comparative efficacies of adjuvants on induction of immunoglobulins (protocols L to O). (A) Total and CCR5-specific serum IgA concentrations obtained with different adjuvants. (B) Total and CCR5-specific serum IgG concentrations obtained with different adjuvants. The mean values and standard deviations for 3 different experiments are shown. (C) Nonspecific depletion of CCR5 receptors on PBMC upon adjuvant administration. The CCR5 density on PBMC was determined by cytofluorimetric analysis before and after immunization with the individual adjuvants to determine whether each adjuvant molecule per se affects the CCR5 expression profile. The proportions express reductions in CCR5 expression on PBMC observed with each adjuvant versus saline immunization. The mean values and standard deviations for 2 different experiments are shown. (D) Immune priming in Peyer's patches with CCR5-specific IgA, total IgA, CCR5-specific IgG, and total IgG profiles. (E) IgG and IgA levels in Peyer's patches from mice immunized with FHV alone. The mean values and standard deviations for 2 independent experiments are shown. (F) HIV-blocking activities of Peyer's patch supernatants from mice immunized with FHV-ECL1-CCR5 (containing IgA specific for CCR5) and FHV alone (containing IgA not specific for CCR5).