FIG 3.

An RNase H2 defect can cause an accumulation of replication-dependent DNA damage that leads to an increase in an aberrant morphology phenotype. The budding index was measured to determine the percentage of cells in each phase of the cell cycle and the percentage of cells with an aberrant morphology phenotype. (A) Representative examples presented as histograms, with error bars indicating the standard deviations. (B, C) Summary of the budding index data for appropriate controls and mutant strains with an increase (B) and no increase (C) in aberrant morphology.