TABLE 1.
Effects of an RNase H2 mutation on the rates of accumulating GCRsa
| Genotype | RDKY no., GCR rate (with 95% CI) (fold increase relative to GCR rate of wild type) |
|
|---|---|---|
| Wild type | rnh203Δ mutant | |
| Wild type | 7239, 3.6 (1.9–14.0) × 10−10 (1) | 7209, 2.0 (0.0–8.9) × 10−10 (0.5) |
| asf1Δ | 7211, 1.4 (0.1–2.4) × 10−8 (39) | 7213, 4.1 (0.2–16.5) × 10−8 (114) |
| cac1Δ | 7214, 3.9 (2.3–7.6) × 10−8 (108) | 7216, 1.0 (0.6–7.6) × 10−9 (3) |
| esc2Δ | 7248, 1.7 (1.0–2.7) × 10−8 (48) | 7250, 2.1 (1.1–6.4) × 10−7 (592) |
| esc4Δ | 7252, 1.3 (1.9–7.3) × 10−8 (36) | 7254, 5.9 (2.4–14.1) × 10−8 (163) |
| exo1Δ | 7256, 1.1 (0.3–2.9) × 10−8 (29) | 7258, 3.4 (0.8–11.7) × 10−9 (9) |
| mre11Δ | 7273, 4.3 (1.7–5.4) × 10−7 (1,194) | 7275, 1.4 (0.5–2.0) × 10−6 (3,972) |
| mus81Δ | 7294, 8.4 (4.5–16.0) × 10−9 (23) | 7296, 2.5 (1.2–4.1) × 10−8 (69) |
| pol30-119 | 7316, 2.9 (1.1–6.7) × 10−9 (8) | 7318, 7.0 (5.3–15.0) × 10−8 (147) |
| rad6Δ | 7385, 2.3 (1.9–7.7) × 10−9 (6) | 7386, 6.5 (2.4–53.0) × 10−9 (18) |
| sgs1Δ | 7414, 6.9 (2.7–11.4) × 10−9 (19) | 7416, 7.6 (6.2–11.7) × 10−8 (211) |
| tel1Δ | 7434, 5.9 (2.0–11.1) × 10−9 (16) | 7436, 8.0 (4.8–54.0) × 10−10 (2) |
a
All strains are isogenic to wild-type RDKY7239 (MATα ura3-52 leu2Δ1 trp1Δ63 his3Δ200 lys2ΔBgl hom3-10 ade2::hisG ade8 hxt13::URA3). 95% CI, 95% confidence interval.