TABLE 3.
Effects of a top1Δ mutation on the GCR rates of rnh203Δ mutantsa
| Genotype | RDKY no., GCR rate (with 95% CI) (fold increase relative to GCR rate of wild type) |
|
|---|---|---|
| Wild type | rnh203Δ | |
| Wild type | 7239, 3.6 (1.9–14.0) × 10−10 (1) | 7209, 2.0 (0.0–8.9) × 10−10 (0.5) |
| top1Δ | 8143, 7.6 (1.6–56.6) × 10−10 (2) | 8141, 5.6 (2.5–30.1) × 10−10 (3) |
| esc2Δ | 7248, 1.7 (1.0–2.7) × 10−8 (48) | 7250, 2.1 (1.1–6.4) × 10−7 (592) |
| esc2Δ top1Δ | 8145, 1.1 (0.5–2.6) × 10−8 (30) | 8147, 4.6 (0.0–21) × 10−9 (13) |
| sgs1Δ | 7414, 6.9 (2.7–11.4) × 10−9 (19) | 7416, 7.6 (6.2–11.7) × 10−8 (211) |
| sgs1Δ top1Δ | 8149, 2.2 (0.7–29.6) × 10−8 (61) | 8151, 8.3 (1.3–50.0) × 10−8 (230) |
a
All strains are isogenic to wild-type RDKY7239 (MATα ura3-52 leu2Δ1 trp1Δ63 his3Δ200 lys2ΔBgl hom3-10 ade2::hisG ade8 hxt13::URA3). 95% CI, 95% confidence interval.