TABLE 4.
Summary of observed genetic interactions with the rnh203Δ mutation
| Mutation | Effect of interacting mutation ona: |
|||
|---|---|---|---|---|
| Growth | Aberrant morphology | GCR rate | Growth in Biogridb | |
| esc2Δ | Strong (rad51Δ suppressed, top1Δ unaffected) | Increased (rad51Δ suppressed, top1Δ suppressed) | Increased (rad51Δ suppressed, top1Δ suppressed) | 1, 2, 3 |
| mgs1Δ | Strong | Increased | Same | — |
| mph1Δ | Strong (rad51Δ suppressed) | Increased (rad51Δ suppressed) | Same (rad51Δ unaffected) | — |
| mre11Δ | Strong | Increased | Increased | 1, 2, 3 |
| rad5Δ | Strong | Same | Same | — |
| rad6Δ | Strong | Same | Same | — |
| rad27Δ | Strong | Same | Same | 1, 2, 3 |
| rad50Δ | Strong | Increased | NDc | 1, 2, 3 |
| rad52Δ | Strong | Increased | Same | 1, 2 |
| rad53Δ | Strong | Same | Same | — |
| rfa1-t33 | Strong | Same | Same | — |
| sgs1Δ | Strong (rad51Δ suppressed, top1Δ unaffected) | Same (rad51Δ unaffected, top1Δ unaffected) | Increased (rad51Δ unaffected, top1Δ unaffected) | 1, 2, 3 |
| top3Δ | Strong | NDc | Same | 2 |
| xrs2Δ | Strong | Increased | NDc | 1, 3 |
| asf1Δ | Moderate (rad51Δ enhanced) | Increased (rad51Δ enhanced) | Increased (rad51Δ unaffected) | — |
| esc4Δ | Moderate | Same | Increased | — |
| ctf4Δ | Weak | Same | ND | 1, 2 |
| mus81Δ | Weak | ND | Increased | 2 |
| rad51Δ | Weak | Same | Same | 1, 2 |
| cac1Δ | None | ND | Reduced | — |
| exo1Δ | None | ND | Reduced | — |
| pol30-119 | None | ND | Increased | — |
| siz1Δ | None | ND | Increased | — |
| tel1Δ | None | ND | Reduced | — |
a
Boldface shows those cases where a genetic interaction was observed. ND, not determined.
b
1, interaction with rnh201Δ; 2, interaction with rnh202Δ; 3, interaction with rnh203Δ; —, no data reported in Biogrid.
c
Interaction was not determined for the specified mutation as a mutation in another gene encoding a subunit in the same protein complex was tested.