FIG 5.

The Myc 3′ WRE suppresses colitis-associated carcinogenesis (CAC). (A) Schematic of the CAC protocol. Myc 3′ WRE^−/− mice and WT littermates were given a single intraperitoneal injection of azoxymethane (AOM) and then subjected to 3 cycles of DSS-induced colitis. After 85 days, mice were sacrificed, and tumors within the distal colon were tallied. (B) Representative images of colons isolated from WT and Myc 3′ WRE^−/− mice subjected to the AOM/DSS protocol. (C) Numbers of tumors in the colons of WT and Myc 3′ WRE^−/− mice subjected to the AOM/DSS protocol. (D) Size of tumors quantified within the colons of mice with the indicated genotypes. In panels C and D, 4 mice were examined per genotype, and errors are standard errors of the means (*, P < 0.05).