TABLE 4.
Clinical, genetic, and phenotypic information of sequence types represented by more than one K. oxytoca isolate
| Sequence type | Isolate | Toxina | Geographic originb | Isolation site | Diagnosisc | Isolation date (mo/yr) | Antibiotic resistance typed | Nosocomial (N)/outpatient (O)e | Clonal complex | Cluster |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 34 | + | AUT (Graz) | Stool | AAHC | 3/2004 | O | A | ||
| 1 | 45 | + | AUT (Graz) | Stool | Follow-up/AAHC | 4/2004 | O | A | ||
| 2 | 56 | + | AUT (Graz) | Stool | AAHC | 4/2004 | O | 2 | A | |
| 2 | 379 | + | ESP | Stool/rectal swab | NA | 5/2009 | CRE | N | 2 | A |
| 4 | 33 | − | AUT (Styria) | Skin | CSSTI | 5/2004 | O | 8 | A | |
| 4 | 73 | − | AUT (Graz) | Stool | Asymptomatic carrier | 4/2004 | ESBL | N | 8 | A |
| 4 | 81 | + | AUT (Graz) | Stool | Asymptomatic carrier | 6/2005 | O | 8 | A | |
| 4 | 204 | + | AUT (Graz) | Stool | AAHC | 8/2008 | ESBL | O | 8 | A |
| 4 | 231 | − | AUT (Graz) | Respiratory tract | Nosocomial pneumonia | 10/2010 | ESBL + CRE | N | 8 | A |
| 4 | 402 | − | AUT (Graz) | Respiratory tract | Pneumonia | 6/2013 | O | 8 | A | |
| 9 | 37 | + | AUT (Graz) | Stool | Asymptomatic carrier | 4/2004 | ESBL | N | A | |
| 9 | 128 | + | AUT (Styria) | Stool | IBD | 3/2007 | O | A | ||
| 9 | 188 | + | AUT (Vienna) | Stool | AAHC | 1/2008 | NA | A | ||
| 9 | 222 | + | AUT (Graz) | Stool | AAHC | 11/2009 | ESBL | O | A | |
| 9 | 232 | + | AUT (Graz) | Blood | AAHC with bacteremia | 8/2010 | O | A | ||
| 9 | 382 | + | AUT (Graz) | Stool | IBD | 8/2013 | O | A | ||
| 9 | 425 | + | GER | Stool | Diarrhea | 2013 | O | A | ||
| 11 | 75 | − | AUT (Graz) | skin | DFS | 4/2004 | O | 4 | B1 | |
| 11 | 400 | − | AUT (Graz) | Respiratory tract | VAP | 6/2013 | N | 4 | B1 | |
| 18 | 113 | − | AUT (Burgenland) | Stool | Asymptomatic carrier | 6/2005 | O | 2 | A | |
| 18 | 336 | + | HKG | Stool | Diarrhea | NA | NA | 2 | A | |
| 33 | 180 | − | AUT (Graz) | Stool | AAHC | 12/2007 | O | 1 | A | |
| 33 | 227 | + | AUT (Vienna) | Stool | AAHC | 6/2010 | O | 1 | A | |
| 36 | 195 | + | AUT (Graz) | Stool | UTI | 1/2008 | N | A | ||
| 36 | 195-H | − | AUT (Graz) | Urinary tract | UTI | 1/2008 | N | A | ||
| 38 | 131 | − | AUT (Styria) | Stool | Asymptomatic carrier | 4/2007 | O | B2 | ||
| 38 | 333 | + | AUT (Salzburg) | Stool | Colitis | 3/2014 | O | B2 | ||
| 40 | 21 | − | AUT (Graz) | Respiratory tract | VAP | 11/2003 | N | B1 | ||
| 40 | 284 | − | AUT (Graz) | Respiratory tract | Nosocomial pneumonia | 2/2012 | N | B1 | ||
| 41 | 23 | − | AUT (Graz) | Respiratory tract | VAP | 11/2003 | N | 3 | B1 | |
| 41 | 389 | − | AUT (Graz) | Respiratory tract | Pneumothorax | 9/2013 | O | 3 | B1 | |
| 44 | 40 | − | AUT (Graz) | Respiratory tract | VAP | 5/2004 | ESBL | N | B1 | |
| 44 | 179 | − | AUT (Styria) | Urinary tract | UTI | 11/2007 | ESBL | O | B1 |
a
Cytotoxicity was assessed via an MTT-based cell culture assay (6).
b
AUT, Austria; ESP, Spain; GER, Germany; HKG, Hong Kong.
c
AAHC, antibiotic-associated hemorrhagic colitis; NA, information not available; CSSTI, complicated skin and skin structure infection; IBD, inflammatory bowel disease; DFS, diabetic foot syndrome; VAP, ventilator-associated pneumonia; UTI, urinary tract infection.
d
All isolates were resistant to ampicillin. ESBL, extended spectrum β-lactamase; CRE, carbapenem-resistant Enterobacteriaceae.
e
Isolates were classified as nosocomial when infection occurred after 48 h of hospitalization.