TABLE 1.
Subset | No. of samples | Resulta |
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---|---|---|---|---|---|---|---|---|
Standard algorithm |
New fourth-generation assay |
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Architect | WB | NAAT | Final | Ab | Ag | Final | ||
A | 357 | Negative | NA | NA | Negative | Negative | Negative | True negative |
3 | Negative | Negative | <37 | Negative | Positive | Negative | False positive | |
2 | Positive | Positive | NA | Positive | Positive | Negative | True positive | |
2 | Positive | Positive | NA | Positive | Positive | Positive | True positive | |
1b | Positive | UD | Detectable | Positive | Positive | Positive | True positive | |
B | 145 | Positive | Positive | NA | Positive | Positive | Negative | True positive |
13 | Positive | Positive | NA | Positive | Positive | Positive | True positive | |
C | 23c | Positive | Negative | <37 | Negative | Negative | Negative | True negative |
4c | Positive | UD | <37 | Negative | Negative | Negative | True negative | |
2c | Positive | Negative | <37 | Negative | Positive | Negative | False positive | |
1c | Positive | UD | <37 | Negative | Positive | Negative | False positive | |
4b | Positive | UD | Detectable | Positive | Positive | Negative | True positive | |
2b | Positive | Negative | Detectable | Positive | Positive | Positive | True positive | |
2b | Positive | Negative | Detectable | Positive | Negative | Positive | True positive | |
1b | Positive | UD | Detectable | Positive | Positive | Positive | True positive | |
1b | Positive | UD | Detectable | Positive | Negative | Positive | True positive | |
3d | Positive | Negative | <37 | Positive | Negative | Negative | False negative | |
3d | Positive | Negative | <37 | Positive | Positive | Negative | True positive | |
1d | Positive | UD | <37 | Positive | Positive | Negative | True positive | |
1e | Positive | Negativef | <37 | Positive | Positive | Negative | True positive |
NA, not applicable; UD, undetermined.
Acute infection.
Architect false-positive result.
Maternal antibodies.
HIV-2 infection.
Our routine confirmatory test detects only antibodies against HIV-1 (New LabBlot HIV-1); this sample was confirmed when assayed with a Western blot assay specific for HIV-2 (New LabBlot HIV-2).