FIG 4.

Entropy plot of each amino acid site and related B cell and T cell epitopes in the preC/C genes of mothers and daughters. The dark-gray lines represent the mothers and the light-gray lines represent the daughters. The entropies of most sites in the mothers were higher than those in daughters, which suggested that more mutations in epitopes were found. Mutations and indels were more common in clones from the mothers, which decreased the infinity by 6- to 89-fold or led to a loss of the epitopes. The epitopes were based on references.