TABLE 2.

Clinical features of patients with discrepant findings of CSF analysis by PCR and culture/microscopy

PCR/culture results and patient no.a	Pathogen detected	Prodromal clinical feature(s)b	Clinical features at admission/during hospitalizationc	Other laboratory findings
PCR positive/culture negative
5	N. meningitidis	Flu-like illness, cough, headaches	Meningism	Gram-positive diplococci detected by microscopy
6	H. influenzae	Headaches	Sopor	H. influenzae also detected in blood culture
7	S. pneumoniae	Headaches, chronic sinusitis	Meningism, organic brain syndrome
8	S. pneumoniae	Flu-like illness, headaches	Meningism, somnolence	S. pneumoniae detected in a former CSF sample collected in another hospital
9	S. agalactiae		Meningism
10	S. pneumoniae	Headaches, reduced general condition	Septic venous sinus thrombosis, meningism, somnolence
11	S. pneumoniae	Coma (GCS3)	Sopor, meningism, coma
12	N. meningitidis	Fever, headaches, WF-syndrome	Meningism, acral necrosis, renal failure, coma
13	L. monocytogenes	Subfebrile, reduced general condition	Meningism, somnolence, organic brain syndrome	L. monocytogenes detected in a former CSF sample collected in another hospital
PCR negative/culture positive
14	S. epidermidis	Somnolence	Sopor, coma, ICP increased, MCS
15	K. pneumoniae	Atypical intracerebral hemorrhage, VPS infection, UTI, polymorbid	Organic brain syndrome, MCS	K. pneumoniae also detected in blood culture and VPS device

^aNumbering corresponds to that for patients in Table 1.

^bGCS3, Glasgow coma scale grade 3; WF, Waterhouse-Friderichsen; VPS, ventriculoperitoneal shunt; UTI, urinary tract infection.

^cICP, intracranial pressure; MCS, minimal conscious state.