TABLE 2.
Drug resistance mutations found in nine genes for 381 different isolates
| Antibiotica | Gene | Codon | Nucleotide | Polymorphism | No. (%) of isolatesb |
|||
|---|---|---|---|---|---|---|---|---|
| IN | MD | PH | SA | |||||
| RIF | rpoB | 511 | CTG→CCG | 0 | 0 | 1 (1.1) | 0 | |
| 512 | AGC→ACC | 0 | 0 | 1 (1.1) | 0 | |||
| 513 | CAA→AAA | 2 (2.3) | 0 | 2 (2.1) | 1 (1.1) | |||
| CAA→CCA | 1 (1.1) | 0 | 0 | 0 | ||||
| 515 | ATG→ATA | 1 (1.1) | 0 | 0 | 0 | |||
| 516 | GAC→GGC | 0 | 0 | 1 (1.1) | 33 (37.1) | |||
| GAC→GTC | 4 (4.5) | 11 (13.9) | 2 (2.1) | 8 (9.0) | ||||
| GAC→TAC | 0 | 2 (2.5) | 2 (2.1) | 0 | ||||
| 522 | TCG→TTG | 0 | 0 | 2 (2.1) | 0 | |||
| 526 | CAC→TAC | 3 (3.4) | 0 | 10 (10.5) | 7 (7.9) | |||
| CAC→TGC | 1 (1.1) | 0 | 3 (3.2) | 0 | ||||
| CAC→AAC | 1 (1.1) | 0 | 0 | 0 | ||||
| CAC→CTC | 0 | 1 (1.3) | 3 (3.2) | 0 | ||||
| CAC→GAC | 0 | 0 | 4 (4.2) | 0 | ||||
| CAC→GGC | 0 | 0 | 1 (1.1) | 0 | ||||
| CAC→CGC | 0 | 0 | 8 (8.4) | 0 | ||||
| CAC→CCC | 0 | 0 | 1 (1.1) | 0 | ||||
| 531 | TCG→TTG | 76 (86.4) | 64 (81.0) | 52 (54.7) | 40 (44.9) | |||
| TCG→TGG | 0 | 1 (1.3) | 5 (5.3) | 0 | ||||
| 533 | CTG→CCG | 0 | 0 | 1 (1.1) | 34 (38.2) | |||
| Total with marker | 88 (100.0) | 79 (100.0) | 95 (100.0) | 89 (100.0) | ||||
| INH | katG | 315 | AGC→ACC | 75 (86.2) | 82 (100.0) | 64 (69.5) | 84 (93.3) | |
| inhA | −8 | T→A | 2 (2.3) | 0 | 0 | 35 (38.9) | ||
| −8 | T→C | 5 (5.7) | 2 (2.4) | 0 | 0 | |||
| −15 | C→T | 17 (19.5) | 40 (48.8) | 34 (37.0) | 32 (35.6) | |||
| ahpC | −46 | G→A | 18 (20.7) | 0 | 0 | 0 | ||
| Total with marker | 87 (100.0) | 82 (100.0) | 92 (100.0) | 90 (100.0) | ||||
| FQL | gyrA | 90 | GCG→GTG | 16 (19.5) | 18 (32.1) | 14 (43.8) | 41 (50.6) | |
| 91 | TCG→CCG | 1 (1.2) | 3 (5.4) | 0 | 0 | |||
| 94 | GAC→AAC | 10 (12.2) | 3 (5.4) | 1 (3.1) | 8 (9.9) | |||
| GAC→CAC | 2 (2.4) | 2 (3.6) | 0 | 0 | ||||
| GAC→TAC | 3 (3.7) | 8 (14.3) | 4 (12.5) | 1 (1.2) | ||||
| GAC→GCC | 13 (15.9) | 7 (12.5) | 1 (3.1) | 3 (3.7) | ||||
| GAC→GGC | 37 (45.1) | 15 (26.8) | 13 (40.6) | 30 (37.0) | ||||
| gyrB | 510 | AAC→ACC | 1 (1.2) | 1 (1.8) | 0 | 0 | ||
| 515 | GCG→GTG | 2 (2.4) | 0 | 0 | 0 | |||
| Total with marker | 82 (100.0) | 56 (100.0) | 32 (100.0) | 81 (100.0) | ||||
| AMI | rrs | 1401 | A→G | 66 (90.4) | 21 (31.8) | 18 (90.0) | 84 (98.8) | |
| 1484 | G→T | 2 (2.7) | 1 (1.5) | 0 | 0 | |||
| eis | −10 | G→A | 0 | 3 (4.5) | 1 (5.0) | 0 | ||
| −12 | C→T | 0 | 40 (60.6) | 0 | 0 | |||
| −14 | C→T | 5 (6.8) | 6 (9.1) | 0 | 1 (1.2) | |||
| −37 | G→T | 1 (1.4) | 0 | 1 (5.0) | 0 | |||
| tlyA | Any | 0 | 0 | 0 | 0 | |||
| Total with marker | 73 (100.0) | 66 (100.0) | 20 (100.0) | 85 (100.0) | ||||
a
RIF, rifampin; FQL, fluoroquinolones; AMI, aminoglycosides; INH, isoniazid.
b
IN, India; MD, Moldova; PH, Philippines; SA, South Africa.