Skip to main content
. 2014 Apr;88(8):4251–4264. doi: 10.1128/JVI.03571-13

FIG 2.

FIG 2

dNSP16 mutant viruses attenuation in vitro and in vivo. (A and B) Virus titers after infection of Calu3 cells (A) or human airway epithelial (HAE) cells (B) with SARS-CoV WT or dNSP16 at an MOI of 0.01. Time zero represents input titers. (C to F) Weight loss (n > 5 for WT and dNSP16 groups) (C), lung virus titer (n = 3 per group) (D), airway resistance (E), and expiratory flow (F) after infection of female BALB/c mice with 105 PFU of SARS-CoV WT or dNSP16. P values based on the Student t test are marked (*, P < 0.05; ***, P < 0.001).