FIG 6.

Pathogenesis after infection of MDA5^−/− or IFIT1^−/− mice with dNSP16. (A to H) Male and female C57BL/6 (black, n > 13 per group), MDA5^−/− (green, n > 13 per group), and IFIT1^−/− (blue, n > 8 per group) mice were infected with SARS-CoV WT (solid lines) or dNSP16 (dashed line) and monitored for weight loss (A to C), virus titer in the lung (D), expiratory flow (E and F), and airway resistance (G and H). For panels E to H, data from mock-infected IFIT1^−/− (two mice) and MDA5^−/− (one mouse) animals were combined to provide a relative baseline for respiratory function. P values based on Student t test and are marked as indicated (*, P < 0.05; **, P < 0.01; ***, P < 0.001).