TABLE 5.
Replication and transmission of H6 avian influenza viruses in guinea pigs
| Virus | Viral titersa (log10 EID50) in: |
No. positive for seroconversion/total no. (HI titers) |
Direct contact transmission | ||
|---|---|---|---|---|---|
| Nasal turbinate | Lung | Inoculated | Contact | ||
| CK/GD/S1312/10 (H6N2) | 3.8, 4.5 | 1.0, 1.0 | 3/3 (160–320) | 3/3 (80–320) | Highly efficient |
| DK/GD/S4192/08 (H6N2) | 3.5, 5.0 | 1.5, 3.5 | 3/3 (160) | 0/3 | None |
| DK/HuB/S1114/09 (H6N2) | 5.0, 5.0 | 1.3, 1.0 | 3/3 (10–80) | 1/3 (10) | Inefficient |
| GS/GD/S1384/10 (H6N2) | 2.5, 3.0 | 2.3, 2.3 | 3/3 (10–40) | 0/3 | None |
| CK/GD/S1311/10 (H6N6) | 4.3, 4.5 | 1.0, 1.0 | 3/3 (40–160) | 3/3 (20–80) | Highly efficient |
| CK/HuN/S4495/10 (H6N6) | 3.0, 4.5 | 1.8, 1.0 | 3/3 (20–40) | 1/3 (20) | Inefficient |
| DK/GD/S3073/10 (H6N6) | 2.3, 2.5 | 1.0, 1.0 | 3/3 (80, 160) | 0/3 | None |
| DK/GD/S4251/10 (H6N6) | 5.0, 4.8 | 5.5, 5.5 | 3/3 (160–320) | 1/3 (80) | Inefficient |
| DK/GD/S1155/11 (H6N6) | 3.5, 5.0 | 3.5, 2.5 | 3/3 (80–160) | 0/3 | None |
| CK/HuN/S3003/09 (H6N6) | 3.0, 2.5 | ND, NDb | 3/3 (10) | 0/3 | None |
a
Viral titers are shown as individual titers for both guinea pigs.
b
ND, virus not detected in sample.