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. 2014 Apr;88(8):3965–3975. doi: 10.1128/JVI.03497-13

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Copyright © 2014 Frederico et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.

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FIG 3 — MuHV-4 colonization of i.p.-inoculated BAFF-R^−/− mice does not recover with time. (a) We infected C57BL/6J (WT) or BAFF-R^−/− mice i.p. with MuHV-4 (10⁵ PFU) and determined the titers of recoverable virus in peritoneal washes and spleens by infectious center assay 7, 13, 20, and 27 days later. Circles show individual mice; crosses show means. BAFF-R^−/− titers were significantly lower at all time points (P < 0.05). (b) The same samples as for panel a were assayed for viral genome load (M2) relative to cellular genome load (APRT) by Q-PCR. Normalized viral genome loads were significantly lower in BAFF-R^−/− mice at all time points (P < 0.03).