FIG 2.

pUL96 is a conserved betaherpesvirus protein critical for CMV maturation. Shown is an amino acid sequence alignment of pUL96 homologs from human CMV (HCMV; YP_081543), RhCMV (YP_068222), CCMV (AAM00734), HHV6 (CAA58360), and HHV7 (YP_073808). Identical amino acids (black) and similar amino acids (gray) are highlighted. The locations of the mutations introduced into the C-terminal region of pUL96 in this study are depicted. The last six amino acids of HCMV_UL96 are termed the EVDDAV cluster.