TABLE 2.

Characteristics for the WT, V2A, and D8A viruses in the presence/absence of 5-FU

Virus and treatment	r (min−1)	K (PFU, ×10−8)	L (min)	B (PFU/cell)	aHa (ml/min)	R (min−1)	E (min)	Predicted rb	Predicted rc
None
WT	0.130 ± 0.002	9.21 ± 1.12	24.5 ± 0.2	25.4 ± 4.4	0.524 ± 0.062	0.877 ± 0.027	13.6 ± 0.2	0.132	0.123
V2Ad	0.089 ± 0.002***	5.01 ± 0.50*	36.2 ± 0.6***	37.2 ± 7.5	0.287 ± 0.028*	0.540 ± 0.049**	19.3 ± 0.3***	0.099	0.092
D8Ad	0.090 ± 0.005**	0.160 ± 0.010***	38.5 ± 1.0***	18.2 ± 1.5	0.111 ± 0.021**	0.400 ± 0.148	20.9 ± 0.9**	0.075	0.064
5-FU
WT	0.021 ± 0.001	0.059 ± 0.010	43.0 ± 0.8	1.73 ± 0.19	0.379 ± 0.052	0.348 ± 0.057	20.1 ± 0.2e	0.013	0.012
V2Ad	0.029 ± 0.002*	0.061 ± 0.003	46.3 ± 0.7*	2.47 ± 0.19*	0.279 ± 0.181	0.283 ± 0.113	33.0e	0.020	0.018
D8Ad	0.030 ± 0.001**	0.015 ± 0.005*	49.0 ± 1.3**	3.01 ± 0.24**	ND	ND	ND	0.022	0.019f

^aFor a cell density of H = 10⁸ cells/ml.

^bPredicted from r = lnB/L.

^cPredicted from r = aH(Be^−Lr − 1).

^dAsterisks indicate significant differences from WT values by t test (*, P < 0.05; **, P < 0.01; ***, P < 0.001).

^eCalculated from two (WT) and one (V2A) of the three replicates due to insufficient viral growth in the other replicates.

^fUsing aH = 0.111.