FIG 6.

Infectivity of parvovirus LuIII and parvoviral vector AAV-T are unimpaired in human sarcoma cells that are protected from VSV by either intrinsic IFN (SW-R) or extrinsic IFN (SW-S + IFN). (A) Micrographs show SW-R cells, cells of an IFN-secreting cell line that is highly VSV resistant but susceptible to parvoviruses LuIII and AAV-T. (B) Measured infectivity of VSV, LuIII, and AAV-T in VSV-sensitive sarcoma SW-S cells either with IFN (+IFN) or without IFN pretreatment and in VSV-resistant sarcoma SW-R cells. n.s., not significant; *, significant by ANOVA. Error bars, SEMs; pfu/c, number of PFU per cell; Kg/c, number of kilogenomes per cell.