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MV-Edm subverts mitophagy to attenuate the innate immune response. In this model, MV-Edm induces an innate immune response via activation of DDX58/MAVS signaling while in parallel stimulating autophagy and mitophagy that degrade DDX58, IFIH1, and mitochondrion-anchored MAVS. SQSTM1 may play a crucial role in tipping the balance of anti- to proviral functions of autophagy, enhancing replication of MV-Edm, since it mediates mitophagy.
