TABLE 2 .
Functional categories of mutations associated with highly resistant (H*R) isolates
| Functional category | No. of determinants | Mutation(s)a associated with H*R isolates in the following strain: |
|||
|---|---|---|---|---|---|
| UK13136 (family A) | ST63/458 (family B) | E2125 (family C) | E4278 (family D) | ||
| Guanine metabolism (category a) | 5 | guaA, guaB | guaA, relA2, prsA | relA2, hpt | |
| Transcription (category b) | 5 | bglG, rpoB, RNA helicase | rpoC | rpiR, rpoB, rpoC | |
| Translation/ribosomal structure (category c) | 9 | rpsM, lysS | rplK | gcp, cysS, valS | lysS, gltX, metS, sua-5 |
| Transport/metabolism (category d) | 5 | pyk, hemC | fbaA | oppB, fruK | |
| Cell division (category e) | 1 | ftsH | |||
| Unknown function (category f) | 5 | HP2, Intergenic | Intergenic | HP1, Intergenic | |
| Total | 30 | ||||
a
Genes potentially involved with induction of a stringent stress response are indicated in boldface print. The fbaA and oppB genes are downregulated by (p)ppGpp-mediated stringent stress response (33). HP stands for hypothetical protein.