Figure 4.

Abnormalities in TgP23H cone photoreceptor morphology arise at P60. Cone inner and outer segments (black arrows) and cone pedicles (inset: black arrowheads) are normal at P14. At P60 cone outer segments (black arrows) show irregular disc stacking and some loss of outer segment length, whereas triadic profiles appear normal (inset: black arrowheads). By P90, TgP23H cone photoreceptors lack outer segments, and triadic profiles in their pedicles are no longer apparent (black arrowheads). At P120, some TgP23H cones with inner segments remain (white arrows), but do not have pedicles (black arrowheads).