Table 3. Putative Classification and Localization of Cryptococcus neoformans H99 Hypothetical Proteins Identified As Differentially Regulated in Biofilmsa.
| acc. number | target P | signal P | TMHMM | ProtFun molecular function/enzyme class/GO | HMMER |
|---|---|---|---|---|---|
| Up-Regulated | |||||
| CNAG_03677T0 | N | amino acid biosynthesis/–/– | |||
| CNAG_07559T0 | N | amino acid biosynthesis/–/immune response | aldose 1-epimerase | ||
| CNAG_06226T0 | M | N | energy metabolism/–/growth factor | ETC complex I subunit conserved region | |
| CNAG_05638T0 | N | energy metabolism/lyase/- | dienelactone hydrolase family | ||
| CNAG_02843T0 | N | metabolism/–/growth factor | RNA recognition motif | ||
| CNAG_03705T0 | N | regulatory function/–/growth factor | eisosome component PIL1 | ||
| CNAG_07522T0 | N | regulatory function/–/transcription regulation | GDP/GTP exchange factor Sec2p | ||
| CNAG_01375T0 | N | regulatory function/–/transcription | cofilin/tropomyosin-type actin-binding and SH3 domain | ||
| CNAG_03463T0 | M | N | translation/–/transcription | eisosome component PIL1 | |
| CNAG_00848T0 | N | translation/ligase/growth factor | |||
| Down-Regulated | |||||
| CNAG_05689T0 | N | amino acid biosynthesis/lyase/growth factor | |||
| CNAG_00012T0 | N | central intermediary metabolism/–/– | oxidoreductase family, NAD-binding | ||
| CNAG_06235T0 | N | central intermediary metabolism/ligase/– | AdoMet dependent proline dimethyltransferase | ||
| CNAG_06511T0 | N | energy metabolism/lyase/– | short chain dehydrogenase | ||
| CNAG_02118T0 | N | replication and transcription/–/transcription regulation | |||
| CNAG_04105T0 | N | translation/–/– | |||
| CNAG_06113T0 | N | translation/-/growth factor | Stm1 and hyaluronan/mRNA binding family | ||
| CNAG_06866T0 | N | translation/-/transcription | |||
| CNAG_03007T0 | N | translation/-/transcription regulation | |||
| CNAG_05251T0 | N | translation/–/transcription regulation | |||
| CNAG_02129T0 | N | translation/ligase/– | |||
| Unique | |||||
| CNAG_06274T0 | N | TM | energy metabolism/–/transporter | cytochrome c oxidase copper chaperone | |
| CNAG_02914T0 | M | N | energy metabolism/lyase/structural | mitochondrial large subunit ribosomal protein | |
| CNAG_05573T0 | N | fatty acid metabolism/–/transcription regulation | cytochrome c oxidase copper chaperone | ||
| CNAG_06749T0 | N | metabolism/lyase/immune response | |||
| CNAG_00668T0 | N | TM | purine and pyrimidine/–/growth factor | ||
| CNAG_04257T0 | N | TM | purine and pyrimidine/–/growth factor | outer membrane protein TOM13 | |
| CNAG_00351T0 | N | regulatory function/–/growth factor | ARP2/3 complex 20 kDa subunit | ||
| CNAG_02739T0 | N | regulatory function/–/transcription regulation | fungal Zn(2)-Cys(6) binuclear cluster | ||
| CNAG_01381T0 | N | TM | translation/–/growth factor | 3′ exoribonuclease family, domain 1 | |
| CNAG_04914T0 | M | N | translation/–/structural | LSM domain | |
| CNAG_06716T0 | N | translation/–/transcription | RNA recognition motif | ||
| CNAG_03361T0 | N | translation/ligase/– | metallo-beta-lactamase superfamily |
a
Target P: (M) mitochondrial; Signal P: (N) no peptide signal; TMHMM: (TM) transmembrane.