Table 2. ACDLogP and Boiling Point of Water, Octanol, and Various Water Miscible Organic Solvents.
| water miscible solvent/antisolvent | boiling pointa (°C) | ACDLogP |
|---|---|---|
| methanol | 65 | –0.72 ± 0.18 |
| ethanol | 78 | –0.19 ± 0.18 |
| n-propanol | 97 | 0.34 ± 0.18 |
| ethylene glycol | 197 | –1.69 ± 0.21 |
| 1,2-propylene glycol | 187 | –1.34 ± 0.22 |
| glycerin | 182 | –2.32 ± 0.49 |
| acetonitrile | 81 | –0.45 ± 0.19 |
| acetone | 56 | –0.16 ± 0.19 |
| dimethyl sulfoxide (DMSO) | 189 | –1.35 ± 0.28 |
| N,N-dimethylformamide (DMF) | 153 | –1.01 ± 0.28 |
| tetrahydrofuran (THF) | 66 | 0.33 ± 0.22 |
| hexafluoroisopropanol (HFIP) | 59 | 1.91 ± 0.79 |
| water | 100 | –1.38 ± 0.21 |
| n-octanol (water immiscible) | 196 | 3.00 ± 0.18 |
a
From Sigma Aldrich Inc.