Table 2. Growth Inhibition Data of Complexes 1–3, 7–9, and 10–12 against HeLa Cells and Corresponding Tumor Specificities.
| drug | HeLa IC50 (μM) | lymph (resting) IC50 (μM) | lymph (stimulated) IC50 (μM) | tumor specificity (TS) | |
|---|---|---|---|---|---|
| PPh3 derivatives | 1 | 2.56 ± 0.12 | 9.05 ± 3.50 | 8.55 ± 3.37 | 3.4 |
| 2 | 2.63 ± 0.10 | 9.53 ± 3.18 | 8.63 ± 3.77 | 3.5 | |
| 3 | 2.56 ± 0.17 | 13.98 ± 10.50 | 5.08 ± 2.48 | 3.7 | |
| dppp derivatives | 7 | 3.07 ± 0.48 | 7.05 ± 2.02 | 5.02 ± 1.72 | 1.9 |
| 8 | 6.96 ± 0.51 | 6.13 ± 2.92 | 2.94 ± 0.91 | 0.7 | |
| 9 | 3.38 ± 0.30 | 18.48 ± 3.88 | 8.16 ± 4.10 | 3.9 | |
| dpph derivatives | 10 | 0.51 ± 0.08 | 18.89 ± 5.66 | 6.68 ± 3.40 | 25.0 |
| 11 | 0.14 ± 0.01 | 18.23 ± 15.90 | 1.38 ± 0.39 | 70.5 | |
| 12 | 4.04 ± 0.49 | 37.74 ± 12.60 | 30.25 ± 11.06 | 8.4 | |
| cis-platin | 0.45 ± 0.09 |