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. 2014 Jan 29;53(4):2058–2067. doi: 10.1021/ic4025926

Table 2. Growth Inhibition Data of Complexes 13, 79, and 1012 against HeLa Cells and Corresponding Tumor Specificities.

  drug HeLa IC50 (μM) lymph (resting) IC50 (μM) lymph (stimulated) IC50 (μM) tumor specificity (TS)
PPh3 derivatives 1 2.56 ± 0.12 9.05 ± 3.50 8.55 ± 3.37 3.4
  2 2.63 ± 0.10 9.53 ± 3.18 8.63 ± 3.77 3.5
  3 2.56 ± 0.17 13.98 ± 10.50 5.08 ± 2.48 3.7
dppp derivatives 7 3.07 ± 0.48 7.05 ± 2.02 5.02 ± 1.72 1.9
  8 6.96 ± 0.51 6.13 ± 2.92 2.94 ± 0.91 0.7
  9 3.38 ± 0.30 18.48 ± 3.88 8.16 ± 4.10 3.9
dpph derivatives 10 0.51 ± 0.08 18.89 ± 5.66 6.68 ± 3.40 25.0
  11 0.14 ± 0.01 18.23 ± 15.90 1.38 ± 0.39 70.5
  12 4.04 ± 0.49 37.74 ± 12.60 30.25 ± 11.06 8.4
  cis-platin 0.45 ± 0.09